Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2
نویسندگان
چکیده
منابع مشابه
Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2
BACKGROUND Hexokinase (HK) is the rate-limiting enzyme in the first reaction of glycolysis. And Hexokinase 2 (HK2) is most closely related to malignant tumor which expresses at higher level compared with normal cells. HK2 plays a pivotal role in tumor initiation and maintenance, which provides a new target for cancer therapy. METHODS Structure-based virtual ligand screening was used in hit id...
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In order to improve the sensitivity of cervical cancer cells to irradiation therapy, we targeted hexokinase 2 (HK2), the first rate-limiting enzyme of glycolysis, and explore its role in cervical cancer cells. We suppressed HK2 expression and/or function by shRNA and/or metformin and found HK2 inhibition enhanced cells apoptosis with accelerating expression of cleaved PARP and caspase-3. HK2 in...
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ژورنال
عنوان ژورنال: Journal of Experimental & Clinical Cancer Research
سال: 2017
ISSN: 1756-9966
DOI: 10.1186/s13046-017-0530-4